Research in our lab seeks to understand the fundamentals of host-microbe interactions in the context of the whole organism. Much of our current interest is focused on the gut microbiota, but we are also interested in how gut commensals affect host immunity and host-pathogen interactions. Our level of investigation spans the range between molecular mechanisms, ecological constraints and impact on evolution. To achieve all this, we are using the nematode Caenorhabditis elegans, a powerful model organism for genetic studies, as a host model. Research in our lab includes three major directions: a) Shaping the structure and function of the Gut microbiota; b) Regulatory mechanisms of innate immune responses; and c) the role of antagonistic pleiotropy in aging.
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