Selected Publications

Paradoxical suppresion of small RNA activity at high Hfq concentrations due to random-order binding. Sagawa S, Shin J-E, Hussein R, Lim HN. Nucleic Acids Res. Accepted.

Quantiative characterization of gene regulation by Rho dependent transcription termination. Hussein R, Lee TY, Lim HN. Biochim Biophys Acta. 2015; doi: 10.1016/j.bbagrm.2015.05.003.

Modulating the frequency and bias of stochastic switching to control phenotypic variation. Hung M, Chang E, Hussein R, Frazier K, Shin J-E, Sagawa S, Lim HN. Nat. Commun. 2014; 5:4574 doi: 10.1038/ncomms5574.

Rapid and robust signaling in the CsrA cascade via RNA-protein interactions and feedback regulation. Adamson DN, Lim HN. Proc Natl Acad Sci U S A. 2013; 110(32):13120-5.

Minimal effect of gene clustering on expression in Escherichia coli. Liang LW, Hussein R, Block DHS, Lim HN. Genetics. 2013. 193(2): 453-466.

See related Issue Highlights

Regulatory consequences of gene translocation in bacteria. Block DHS, Hussein R, Liang LW, Lim HN. Nucleic Acids Res. 2012; 40(18):8979-92.

Direct comparison of small RNA and transcription factor signaling. Hussein R, Lim HN. Nucleic Acids Res. 2012; 40(15): 7269-79.

Fundamental relationship between operon organization and gene expression. Lim HN, Lee Y, Hussein R. Proc Natl Acad Sci U S A. 2011; 108(26): 10626-31.

Essential requirements for robust signaling in Hfq dependent small RNA networks. Adamson DN, Lim HN. PLoS Comput Biol. 2011; 7(8): e1002138.

Disruption of small RNA signaling caused by competition for Hfq. Hussein R., Lim HN. Proc Natl Acad Sci U S A. 2011; 108(3): 1110–5.

A multistep epigenetic switch enables the stable inheritance of DNA methylation states. Lim HN, van Oudenaarden A. Nat Genet. 2007; 39(2): 269-75.