Steve is studying the evolution of dosage compensation in
Drosophila miranda's neo-sex chromosome system.
What is the extent of dosage compensation in D.
miranda? How does dosage compensation arise along the
neo-X chromosome? Is there a link between dosage
compensation and the evolution of male-biased gene
expression? Steve is addressing these question (and more)
by employing whole transcriptome RNA-sequencing combined
with gene-by-gene TaqMan qRT-PCR expression assays and
ChIP-PCR binding assays.
Steven Lockton
Education
Postdoctoral scholar, University of California, Berkeley
September 2008 – present
Advisor: Prof. Doris Bachtrog
Ph.D., University of California, Irvine October 2003
– August 2008
Advisor: Prof. Brandon S. Gaut
B.Sc. (Hons.) Genetics, University of Wales, Cardiff
September 1996 – June 2000
Publications
Lockton S, Gaut
BS (2009). The Evolution of Transposable Elements in
Natural Populations of
Self-Fertilizing Arabidopsis thaliana
and its Outcrossing
Relative Arabidopsis
lyrata.
Submitted to BMC
Evolutionary Biology. In revision.
Bachtrog D, Toda N, Lockton S (2009). Dosage compensation
and demasculinization of X
chromosomes in Drosophila. Submitted to PloS Biology
Lockton S,
Gaut BS (2009). The Contribution of Transposable Elements
to Expressed Coding
Sequence in Arabidopsis
thaliana.
Journal of Molecular
Evolution. 2009
68: 80-89
Lockton S, Ross-Ibarra J, Gaut BS (2008). Demography and
weak selection drives patterns of
transposable element diversity in natural populations
of Arabidopsis
lyrata.
Proceedings of
the National Academy of Sciences USA
105: 13965-13970
Lockton S, Gaut BS (2005). Plant conserved non-coding
sequences and paralogue evolution.
Trends in
Genetics 21: 60
–65
MacDonald C, Brookes CP, Edwards KJ, Baker D, Lockton S
& Loxdale HD (2003).
Microsatellite isolation
and characterization in the beneficial parasitoid
wasp Diaeretiella
rapae (Hymenoptera: Braconidae:
Aphidiinae).
Molecular Ecology
Notes 3: 601-603
Presentations
June 2009 – Contributed poster, Society for Molecular
Biology & Evolution meeting, Iowa City,
Iowa: Evolution of Dosage Compensation in
Drosophila miranda
June 2007
– Contributed talk, Society for Molecular Biology
& Evolution meeting, Halifax, Nova
Scotia, Canada: Population Genetics of Arabidopsis Transposable
Elements
March 2007 – Invited speaker, University of
California San Diego, section of Ecology, Behavior,
and Evolution seminar series: Evolutionary Genetics
of Arabidopsis
Transposable Elements
October 2006 – Contributed talk, UCI Department of
Ecology and Evolutionary Biology
Graduate Student Symposium: The contribution of
Transposable Elements to expressed
coding sequence in Arabidopsis thaliana
Awards
UC Irvine Graduate Dean’s Dissertation Fellowship
2008
UC Irvine GAANN Fellowship Award 2007
UC Irvine GAANN Fellowship Award 2006
UC Irvine William D. Redfield Graduate Fellowship Award
2006
Teaching
Guest Lecturer, University of California, Irvine
• Spring 2008: Genes in populations and the
Hardy-Weinberg Law in Bio E137 - Genetics
of Complex Traits
• Fall 2007 & Winter 2008: Bacteria & Viruses
in Bio 1a - Introduction to
Life Sciences
• Spring 2006: Transposable Elements
in Bio138 - Advanced
Evolutionary Biology
Teaching Assistant, University of California, Irvine
2003-2008
• Bio 7 – Biostatistics
• Bio 135 - Molecular Evolution
• Bio 115 - Laboratory Evolution
• Bio 1a - Introduction to Life Sciences
• Bio 94 - Organisms to Ecosystems
• EE 208 - Organismal Biology
• Bio 94 - Processes in Ecology and Evolution
• Bio 100 - Experimental Biology Laboratory