Research in the Nachman lab addresses a range of basic questions in population genetics and genomics. Broadly, we are interested in understanding how genetic variation in natural populations is shaped by the interplay of migration, mutation, selection, recombination, drift, and changes in population size. We study the genetic details of how new species arise as well as the genetics of adaptation. Most of our work is on mammals with a particular emphasis on humans and mice.Major current projects include:
We use a variety of approaches including field work, controlled crosses in the laboratory, genomic tools, molecular biological approaches, and computational analysis of large datasets.