The recent discovery of RFamide-related peptide (RFRP), a powerful inhibitor of the reproductive system, has opened the door to a new realm of scientific investigation via novel manipulations of the hypothalamic-pituitary-gonadal (HPG) axis. Currently, I’m investigating the presence and action of this novel neuropeptide in domestic cats.

It’s not hyperbole to state that nothing is known about RFRP in felines, or any carnivore for that matter.

Furthermore, without data on this critical component of the vertebrate reproductive system, we will not fully understand feline reproduction and it will remain problematic to manipulate it in vivo.  By defining RFRP’s role in feline reproduction, this research aims to lay the groundwork for the development of a non-surgical contraceptive applicable to overpopulated feral cats.

This study has been made possible via a joint-collaboration between the Bentley Lab at UC Berkeley and Drs. Pierre Comizzoli and David Wildt at the Smithsonian Conservation Biology Institute at the National Zoological Park in Washington DC.

Contact information: mnmiller@berkeley.edu,

                                    millermn@si.edu