Research
Interests
The research done in this group is on mathematical population genetics
with emphasis on models related to human population genetics. At the
present time,
the main topics of study are as follows:
-
population genetics of human genetic diseases, including
linkage disequilibrium mapping, estimation of allele age, testing for
natural selection, and modeling founder effects;
-
analysis of human genetic diversity, with the goal of developing methods
for inferring historical patterns of migration and population growth
from genetics samples from contemporary populations and from recent
fossils,
-
analysis of strong balancing selection caused by overdominance in
fitness and by genetic self-incompatibility systems,
-
modeling the genetic response to infectious diseases,
-
and interpreting genetic data from a geographically subdivided population.
Other topics, such as quantitative genetics, genomics, and RNA
editing, rise and fall in popularity depending on who is in the group.
Our research is done using a combination of analytic theory and computer
simulations, with a strong bias towards the analysis of data and
testing of models.